Understanding how aging and inflammation contribute to blood cancer development
Assessing the Interplay Between Inflammatory Signaling and Epigenetic Dysregulation in Age-associated Clonal Hematopoiesis and Leukemia Initiation
This study is looking at how getting older can influence the development of blood cancers like acute myeloid leukemia (AML) by exploring how inflammation and genetic changes in blood cells play a role, especially in older adults.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-11080441 on NIH RePORTER |
What this research studies
This research investigates how aging affects the development of blood cancers, particularly acute myeloid leukemia (AML), by examining the role of inflammation and genetic mutations in blood cells. It focuses on clonal hematopoiesis, a condition where certain blood cells acquire mutations that may lead to cancer. The study aims to uncover the mechanisms by which inflammation associated with aging promotes the growth of these mutated cells, potentially leading to leukemia. By using animal models, researchers will explore how these processes differ between young and aged organisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 45 and above, who may be at risk for blood cancers like AML.
Not a fit: Patients who are younger than 45 or those without any signs of clonal hematopoiesis or blood cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating blood cancers in older adults.
How similar studies have performed: Other research has shown promising results in understanding the relationship between aging, inflammation, and cancer development, suggesting that this approach could yield valuable insights.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Trowbridge, Jennifer Jean — Jackson Laboratory
- Study coordinator: Trowbridge, Jennifer Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.