Understanding how aging and cognitive decline affect brain cells in Alzheimer's disease
Uncoupling Age- Versus Cognitive-Related Cellular Senescence in Alzheimer's Disease
This study is looking at how aging and brain changes related to Alzheimer's disease affect brain cells, using a special imaging technique to better understand what happens in the brain as the disease progresses, which could help find new ways to treat Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10896358 on NIH RePORTER |
What this research studies
This research investigates the differences between age-related and cognitive-related cellular changes in the brains of individuals with Alzheimer's disease. Using a cutting-edge imaging technique called multiplexed ion beam imaging (MIBI), the study aims to identify how senescent cells in the brain contribute to the progression of Alzheimer's. By examining both neurons and glial cells, the research seeks to clarify the mechanisms that lead to cognitive decline in aging individuals. This could provide insights into potential therapeutic targets for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
Not a fit: Patients who are not experiencing cognitive decline or do not have Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting specific cellular processes.
How similar studies have performed: Previous research using similar imaging techniques has shown promise in understanding cellular changes in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Bendall, Sean Curtis — Stanford University
- Study coordinator: Bendall, Sean Curtis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.