Understanding how aging and Alzheimer's disease affect the creation of new brain cells
Endogenous barcoding to determine complex dynamics of adult neurogenesis in aging and Alzheimer's disease
This study is looking at how new brain cells are made in adults and how this process changes with age and Alzheimer's disease, and it aims to help find better ways to support memory and thinking for people dealing with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-11076661 on NIH RePORTER |
What this research studies
This research investigates the process of neurogenesis, or the formation of new neurons, in the adult brain, particularly focusing on how this process is influenced by aging and Alzheimer's disease. By using a novel technique called endogenous barcoding, researchers aim to trace the development and lineage of neural stem cells in the hippocampus, a brain region crucial for memory and learning. The study seeks to differentiate the effects of aging from those caused by Alzheimer's, which could lead to new strategies for improving cognitive function in affected individuals. Patients may be involved in providing biological samples or participating in assessments related to cognitive health.
Who could benefit from this research
Good fit: Ideal candidates for participation include adults aged 65 and older, particularly those experiencing cognitive decline or at risk for Alzheimer's disease.
Not a fit: Patients under the age of 65 or those without cognitive impairment may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance or restore cognitive function in older adults and those with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding neurogenesis and its implications for cognitive health, suggesting that this approach could yield valuable insights.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Enikolopov, Grigori N — State University New York Stony Brook
- Study coordinator: Enikolopov, Grigori N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.