Understanding how aging and Alzheimer's disease affect the brain in three dimensions
Official title: Core B: Biospecimen Core
Funded at Columbia University Health Sciences · NIH-10935934 · Data updated 2026-11-12
This study is looking at how aging and Alzheimer's disease affect the brain by examining brain tissue samples, and it's designed to help improve our understanding and treatment of Alzheimer's for those living with the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $246,506 |
| NIH project number | 5U19AG074862-02 |
| Project ID | NIH-10935934 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing cognitive decline related to aging.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on examining the effects of aging and Alzheimer's disease on the brain using advanced techniques that analyze brain tissue at a cellular level. By collecting high-quality human brain samples, the study aims to explore how different pathologies relate to cognitive decline. Patients' brain tissues will be analyzed to provide insights into the molecular changes associated with Alzheimer's, which could lead to better understanding and treatment options. The research involves collaboration with multiple institutions to ensure a comprehensive collection of data.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of Alzheimer's disease and potentially new therapeutic strategies for patients.
How similar studies have gone: Previous research using similar approaches in studying Alzheimer's disease has shown promising results, indicating the potential for significant advancements in understanding the condition.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Kapasi, Alifiya — Columbia University Health Sciences
- Study coordinator: Kapasi, Alifiya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.