Understanding how aging and Alzheimer's Disease affect brain health and memory.
Comparison of normal aging with Alzheimer's Disease: cellular, synaptic, and vascular indices affecting brain plasticity and neurogenesis
['FUNDING_R01'] · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · NIH-11143206
This study looks at how aging affects brain health and memory by comparing older adults with and without Alzheimer's, to learn more about the brain's ability to grow new cells and connections, which could help improve understanding and treatment of memory issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11143206 on ClinicalTrials.gov |
What this research studies
This research investigates the differences in brain health between normal aging and Alzheimer's Disease, focusing on how certain cells and blood vessels in the brain contribute to memory and cognitive functions. The study examines the role of specific proteins that are essential for the growth of new brain cells and the connections between them. By comparing older adults with and without Alzheimer's, the research aims to uncover how aging impacts brain plasticity and the formation of new neurons, which could lead to better understanding and treatment of cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above, including those with normal cognitive function and those diagnosed with Alzheimer's Disease.
Not a fit: Patients under the age of 65 or those with other neurological conditions unrelated to aging or Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing brain health and memory in older adults, particularly those at risk for Alzheimer's Disease.
How similar studies have performed: Previous research has shown promising results in understanding neurogenesis and vascular changes in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOLDRINI, MAURA — NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
- Study coordinator: BOLDRINI, MAURA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.