Understanding how aging affects vaccine responses in older adults
High-resolution single cell profiling of vaccine responsiveness in the elderly
['FUNDING_R01'] · JACKSON LABORATORY · NIH-10582693
This study is looking at how aging affects the immune system in older adults and how that might change their response to flu shots, with the goal of finding ways to make vaccines work better for them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JACKSON LABORATORY (nih funded) |
| Locations | 1 site (BAR HARBOR, UNITED STATES) |
| Trial ID | NIH-10582693 on ClinicalTrials.gov |
What this research studies
This research investigates how the immune system in older adults changes with age and how these changes impact their responses to flu vaccinations. By using advanced techniques like single cell profiling, the study aims to identify specific immune cell types and their functions that decline with age. This approach allows researchers to gain a detailed understanding of the immune response in elderly individuals, which has been overlooked in previous studies. The findings could help improve vaccine effectiveness for older adults, ensuring better health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and above, who are receiving flu vaccinations.
Not a fit: Patients who are younger than 65 years old or those who do not receive flu vaccinations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to enhanced vaccine strategies that improve immune responses in older adults, ultimately protecting their health and independence.
How similar studies have performed: Previous research has shown promise in understanding immune responses in aging populations, but this specific approach using single cell profiling is relatively novel.
Where this research is happening
BAR HARBOR, UNITED STATES
- JACKSON LABORATORY — BAR HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: UCAR, DUYGU — JACKSON LABORATORY
- Study coordinator: UCAR, DUYGU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.