Understanding how aging affects urinary function in men
Elucidating hallmarks of aging in the development of lower urinary tract dysfunction (LUTD)
This study looks at how getting older affects the prostate and can cause problems with urination, and it aims to find out if certain treatments can help improve urinary health for older men.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10906847 on NIH RePORTER |
What this research studies
This research investigates the impact of aging on the prostate, specifically how age-related changes lead to lower urinary tract dysfunction (LUTD). The study focuses on mitochondrial dysfunction and its role in prostate aging and associated urinary symptoms. By using various chemical inhibitors, researchers aim to explore the mechanisms behind prostate fibrosis and its effects on urinary health. This research could provide insights into potential therapeutic targets for improving urinary function in aging men.
Who could benefit from this research
Good fit: Ideal candidates for this research are older men experiencing urinary symptoms related to prostate health.
Not a fit: Patients who are younger than 21 or do not have urinary symptoms related to prostate dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate urinary symptoms in older men.
How similar studies have performed: Previous research has shown promising results in understanding aging mechanisms in other organs, but this specific focus on the prostate and mitochondrial dysfunction is relatively novel.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Ricke, William a — University of Wisconsin-Madison
- Study coordinator: Ricke, William a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.