Understanding how aging affects treatment responses in blood cancers.
Cellular Heterogeneity and Aging in MDS and AML
['FUNDING_OTHER'] · VA EASTERN COLORADO HEALTH CARE SYSTEM · NIH-10911085
This study is looking at how changes in the way our cells handle RNA as we age might affect how well older patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) respond to treatment, with the hope of finding better ways to help them.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VA EASTERN COLORADO HEALTH CARE SYSTEM (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10911085 on ClinicalTrials.gov |
What this research studies
This research investigates how age-related changes in RNA processing affect the progression and treatment resistance of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). By analyzing the molecular profiles of cancer cells from older patients, the study aims to identify specific RNA processing patterns that could predict how well patients respond to existing therapies. The research employs advanced sequencing techniques to examine these patterns at a single-cell level, providing insights into the heterogeneity of these diseases. Ultimately, the goal is to improve treatment efficacy for older patients suffering from these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and above, who are diagnosed with MDS or AML.
Not a fit: Patients under the age of 65 or those without a diagnosis of MDS or AML may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for older patients with MDS and AML, improving their chances of recovery.
How similar studies have performed: Previous research has shown promise in understanding cancer heterogeneity and treatment responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- VA EASTERN COLORADO HEALTH CARE SYSTEM — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GILLEN, AUSTIN E — VA EASTERN COLORADO HEALTH CARE SYSTEM
- Study coordinator: GILLEN, AUSTIN E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.