Understanding how aging affects the success of vascular access for dialysis patients
Official title: BCCMA: Cardiovascular Remodeling following Arteriovenous Fistula Creation: Aging Contributes to Adverse Arteriovenous Fistula Remodeling
Funded at VA Salt Lake City Healthcare System · NIH-10924543 · Data updated 2026-11-12
This study is looking at why older patients sometimes have trouble with the creation of arteriovenous fistulas (AVFs) needed for dialysis, and it hopes to find ways to make these procedures more successful so that patients can have a better quality of life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Salt Lake City Healthcare System NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01BX006078-01A2 |
| Project ID | NIH-10924543 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those aged 65 and above, who require hemodialysis and are at risk of AVF maturation failure.
✕Less likely to help
Patients who are younger than 65 years old or those who do not require hemodialysis may not benefit from this research.
What this research studies
This research investigates the challenges faced by older patients in successfully developing arteriovenous fistulas (AVFs), which are essential for hemodialysis. It aims to uncover the biological mechanisms behind AVF maturation failure, particularly focusing on how aging impacts the cells involved in this process. By studying factors like endothelial cell senescence and collagen in smooth muscle cells, the research seeks to identify potential therapies that could improve AVF outcomes for patients. The ultimate goal is to enhance the success rates of AVFs, thereby improving the quality of life for patients requiring dialysis.
Why it matters
Potential benefit: If successful, this research could lead to improved vascular access options for older dialysis patients, reducing complications and enhancing their treatment experience.
How similar studies have gone: While there is ongoing research in vascular access for dialysis, this specific focus on aging and AVF maturation mechanisms is relatively novel and has not been extensively tested.
Where this research is happening
-
VA Salt Lake City Healthcare System
Salt Lake City, United States Active
Researchers
- Principal investigator: Shiu, Yan-Ting E. — VA Salt Lake City Healthcare System
- Study coordinator: Shiu, Yan-Ting E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.