Understanding how aging affects the risk of developing peripheral neuropathy
Measuring cellular senescence to predict and prevent peripheral neuropathy
This study is looking at how aging and certain health factors can help us understand who might be more likely to develop painful peripheral neuropathy, especially in older adults, so we can find better ways to prevent it.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sapere Bio, INC. NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10673718 on NIH RePORTER |
What this research studies
This research investigates the role of cellular senescence in predicting and preventing peripheral neuropathy, a painful condition that often affects older adults. By examining how aging contributes to the risk of developing this condition, the study aims to identify patients who may be more vulnerable to neuropathy due to various factors, including previous medical treatments and chronic diseases. The approach involves analyzing biological markers related to aging and senescence to better understand individual risk profiles. Ultimately, this research seeks to improve prevention strategies for those at high risk of developing peripheral neuropathy.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are at risk of developing peripheral neuropathy due to age-related conditions or previous medical treatments.
Not a fit: Patients who are not at risk of peripheral neuropathy or who are younger and healthy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for peripheral neuropathy, improving quality of life for older patients.
How similar studies have performed: Previous research has shown that understanding cellular senescence can provide insights into neurodegenerative diseases, suggesting potential for success in this novel approach to peripheral neuropathy.
Where this research is happening
Durham, United States
- Sapere Bio, INC. — Durham, United States (Active)
Researchers
- Principal investigator: Mitin, Natalia — Sapere Bio, INC.
- Study coordinator: Mitin, Natalia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.