Understanding how aging affects the human lung and blood cells
Official title: Dissecting the cellular and spatial tissue clock of the human lung and peripheral blood
Funded at Icahn School of Medicine at Mount Sinai · NIH-11134150 · Data updated 2026-11-12
This study is looking at how our lungs and blood change as we get older, with the hope of finding new ways to help older adults breathe better and stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 15, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $789,664 |
| NIH project number | 1R01AG089078-01A1 |
| Project ID | NIH-11134150 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who are experiencing age-related respiratory issues or are interested in understanding the effects of aging on lung health.
✕Less likely to help
Patients who are younger or do not have any age-related respiratory conditions may not benefit from this research.
What this research studies
This research investigates the cellular and molecular changes that occur in the lungs and blood as people age. By utilizing advanced techniques like single-cell RNA sequencing and spatial transcriptomics, the study aims to identify how age impacts the cellular environment in these tissues. The goal is to uncover new therapeutic targets that could help slow down lung aging and reduce the risk of respiratory diseases in older adults. Patients may benefit from insights that could lead to improved treatments for age-related respiratory conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow lung aging and improve respiratory health in the elderly.
How similar studies have gone: Previous research has shown promise in understanding aging mechanisms in other tissues, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Tsankov, Alexander Minchev — Icahn School of Medicine at Mount Sinai
- Study coordinator: Tsankov, Alexander Minchev
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.