Understanding how aging affects the human brain in neurodegenerative diseases
Mapping the landscape of the aged human brain for neurodegenerative disease models
['FUNDING_R21'] · UNIVERSITY OF WASHINGTON · NIH-10931824
This study is looking at how our brains change as we get older, especially in connection with diseases like Alzheimer's, to help find better ways to understand and treat these age-related brain issues.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10931824 on ClinicalTrials.gov |
What this research studies
This research investigates the biological processes of aging in the human brain, particularly in relation to neurodegenerative diseases like Alzheimer's. By utilizing advanced human cell models and analyzing extensive data from post-mortem brain studies, the research aims to uncover the genetic and cellular changes that occur with aging. This approach seeks to bridge the gap between laboratory findings and human biology, potentially leading to better understanding and treatment options for age-related brain disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are experiencing cognitive decline or have a family history of Alzheimer's disease.
Not a fit: Patients with early-onset Alzheimer's or those with non-neurodegenerative cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies and interventions for patients suffering from Alzheimer's disease and related dementias.
How similar studies have performed: Previous research using human cell models and multi-omic data has shown promise in understanding neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YOUNG, JESSICA ELAINE — UNIVERSITY OF WASHINGTON
- Study coordinator: YOUNG, JESSICA ELAINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease