Understanding how aging affects the growth of new brain cells in the hippocampus
Mechanistic study of declining hippocampal neurogenesis in the aging brain
This study looks at how the brain's ability to create new cells in an important area called the hippocampus decreases as we get older, especially in relation to Alzheimer's disease, and it hopes to find ways to improve brain health for older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10765686 on NIH RePORTER |
What this research studies
This research investigates how the ability of the brain to generate new neurons in the hippocampus declines as people age, particularly in relation to Alzheimer's disease. By examining the mechanisms behind this decline, the study aims to uncover why fewer new neurons are produced in older adults and how this affects cognitive function. The research involves analyzing brain samples and conducting experiments to understand the biological processes at play. Patients may benefit from insights that could lead to new treatments for age-related cognitive disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those experiencing cognitive decline or diagnosed with Alzheimer's disease.
Not a fit: Patients who are younger than 21 years old or do not have any cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to enhance cognitive function in older adults and those with Alzheimer's disease.
How similar studies have performed: Previous studies have shown promising results in understanding neurogenesis in aging, suggesting that this research could build on established findings.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Ge, Shaoyu — State University New York Stony Brook
- Study coordinator: Ge, Shaoyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.