Understanding how aging affects the effectiveness of CAR T cell therapy for cancer treatment
Defining the Role of Senescence in Limiting Therapeutic Efficacy of CAR T Cells
This study is looking at how aging in certain immune cells might make CAR T cell therapy less effective for fighting cancer, and it hopes to find ways to improve this treatment for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10907783 on NIH RePORTER |
What this research studies
This research investigates the role of cellular aging, specifically senescence, in reducing the effectiveness of CAR T cell therapy, a promising treatment for certain cancers. The study aims to identify specific markers of senescence in T cells and how these markers relate to the cells' ability to fight cancer. By examining the relationship between telomerase activity and T cell function, the research seeks to uncover ways to enhance the efficacy of CAR T therapy. Patients may benefit from insights that could lead to improved treatment strategies for cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing CAR T cell therapy for B cell malignancies.
Not a fit: Patients who are not receiving CAR T cell therapy or those with solid tumors that are not targeted by CAR T therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective CAR T cell therapies, improving outcomes for cancer patients.
How similar studies have performed: Previous research has shown that understanding T cell exhaustion can improve CAR T cell therapy, suggesting that exploring senescence may also yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Murty, Tara — Stanford University
- Study coordinator: Murty, Tara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.