Understanding how aging affects the development of ovarian cancer
Defining the impact of stromal aging on ovarian cancer initiation
This study is looking at how getting older affects the way certain cells in the fallopian tube interact with cancer cells, which could help us understand how to spot and prevent ovarian cancer earlier.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11075919 on NIH RePORTER |
What this research studies
This research investigates how aging influences the interactions between stromal cells and cancer initiating cells in the fallopian tube, which is the origin of most high-grade serous ovarian cancers. It focuses on the role of senescent cells and their secretions in creating a microenvironment that may promote cancer formation. By studying how mesenchymal stromal cells change with age and contribute to cancer risk, the research aims to uncover mechanisms that could lead to better early detection and prevention strategies for ovarian cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are women aged 60 and above, particularly those with a family history of ovarian cancer or other risk factors.
Not a fit: Patients who are younger than 60 or those without any risk factors for ovarian cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for early detection and prevention of ovarian cancer, particularly in older women.
How similar studies have performed: Other research has shown promising results in understanding the role of aging in cancer development, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Coffman, Lan — University of Pittsburgh at Pittsburgh
- Study coordinator: Coffman, Lan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.