Understanding how aging affects the development of acute myeloid leukemia
Official title: The impact of reduction of cellular senescence on age-related epigenetic heterogeneity
Funded at University of Southern California · NIH-11123718 · Data updated 2026-11-12
This study is looking at how getting older affects the development of acute myeloid leukemia (AML) in older adults, especially by examining certain genetic changes in blood stem cells, to help find new ways to prevent this cancer as people age.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $374,770 |
| NIH project number | 7U01CA271830-04 |
| Project ID | NIH-11123718 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 65 and older, particularly those with risk factors for acute myeloid leukemia.
✕Less likely to help
Patients under the age of 65 or those without risk factors for acute myeloid leukemia may not benefit from this research.
What this research studies
This research investigates the relationship between aging and the progression of acute myeloid leukemia (AML) in older adults, particularly focusing on the role of specific genetic mutations in blood stem cells. By studying how age-related changes in the bone marrow environment influence the behavior of these cells, the research aims to uncover the underlying mechanisms that lead to leukemia. The team will utilize advanced techniques in epigenomics and computational analysis to explore these interactions, with the goal of identifying potential therapeutic strategies to prevent the onset of AML in the aging population.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies for acute myeloid leukemia in older adults.
How similar studies have gone: Previous research has shown promising results in understanding the genetic and epigenetic factors involved in leukemia, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Li, Sheng — University of Southern California
- Study coordinator: Li, Sheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.