Understanding how aging affects the brain's ability to connect events over time

Uncovering Neural Substrates of Diminished Temporal Binding Capacity in Aging

NIH-funded research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · NIH-10708806

This study looks at how aging and certain brain disorders affect the way our brains connect different experiences and memories, especially focusing on a part of the brain called the hippocampus, to help find new ways to support better thinking and emotional health in older adults.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionNew York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded
Lab location1 site (New York, United States)
Project IDNIH-10708806 on NIH RePORTER

What this research studies

This research investigates how the brain's ability to link different stimuli and events diminishes with aging and related neuropsychiatric disorders. It focuses on understanding the neural changes that contribute to this decline, which is crucial for cognitive and emotional health in older adults. By studying specific brain regions, particularly the hippocampus, the research aims to uncover the underlying mechanisms that lead to these impairments. The findings could pave the way for new interventions to improve cognitive function in aging populations.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or related neuropsychiatric symptoms.

Not a fit: Patients who are not experiencing cognitive decline or are younger adults may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved strategies for enhancing cognitive and emotional health in older adults.

How similar studies have performed: Previous research has shown promising results in understanding brain function related to cognitive processes, suggesting that this approach could yield valuable insights.

Where this research is happening

New York, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Cognition Disorderscognitive diseasecognitive disordercognitive syndromeDisease
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.