Understanding how aging affects the brain and resilience to Alzheimer's disease
VULNERABILITY AND RESILIENCY IN THE AGING ADULT BRAIN CONNECTOME (AABC)
['FUNDING_OTHER'] · WASHINGTON UNIVERSITY · NIH-10909087
This study is looking at how the brains of healthy older adults change over time, focusing on things like stress and lifestyle, to help find early signs of memory issues and ways to protect against Alzheimer's and similar conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10909087 on ClinicalTrials.gov |
What this research studies
This research investigates the aging adult brain by following a group of over 1,000 healthy individuals for up to 10 years. It uses advanced neuroimaging, cognitive testing, and blood samples to track changes in brain health and cognitive function over time. The study focuses on various factors such as stress, lifestyle, and menopause that may influence brain health and resilience against Alzheimer's disease and related dementias. By analyzing these factors, the research aims to identify early indicators of cognitive decline and potential protective mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are healthy adults aged 21 and older who are willing to participate in long-term follow-up assessments.
Not a fit: Patients who are already diagnosed with advanced Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for Alzheimer's disease and related dementias.
How similar studies have performed: Similar research approaches have shown promise in understanding brain aging and resilience, building on findings from the Human Connectome Project.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANCES, BEAU M — WASHINGTON UNIVERSITY
- Study coordinator: ANCES, BEAU M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.