Understanding how aging affects the brain and Alzheimer's disease using advanced imaging techniques
Official title: Multiscale Modeling of Brain Aging and Alzheimer’s Disease with MRI, Pathology and Proteomics
Funded at New York University School of Medicine · NIH-10933720 · Data updated 2026-11-12
This study is looking at how getting older affects the brain and can lead to Alzheimer's and similar conditions, using special imaging techniques to spot early signs of brain changes, which could help identify people at risk and lead to ways to prevent Alzheimer's.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $254,250 |
| NIH project number | 1R21AG087904-01 |
| Project ID | NIH-10933720 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults, particularly those over 100 years old, who may be at risk for Alzheimer's disease or related dementias.
✕Less likely to help
Patients who are not experiencing cognitive decline or do not have risk factors for Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates how aging impacts the brain and contributes to Alzheimer's disease and related dementias. By utilizing advanced diffusion MRI techniques, the study aims to identify early signs of brain aging and neurodegeneration, which could help in recognizing individuals at risk. The approach focuses on understanding the role of white matter and various pathological processes involved in brain aging. Patients may benefit from insights that could lead to preventive measures against Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and intervention strategies for Alzheimer's disease, improving patient outcomes.
How similar studies have gone: Previous research using advanced imaging techniques has shown promise in understanding brain aging and Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Fieremans, Els — New York University School of Medicine
- Study coordinator: Fieremans, Els
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.