Understanding how aging affects the body's response to foreign materials
Official title: Senescence in the Foreign Body Response Across Lifespan
Funded at Johns Hopkins University · NIH-11058433 · Data updated 2026-11-12
This study is looking at how aging cells that don’t divide anymore affect the immune system's response to things like implants, and it hopes to find ways to better understand and manage issues that can arise from these materials as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $594,459 |
| NIH project number | 5R01AG082965-02 |
| Project ID | NIH-11058433 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have received or are considering receiving implants or biomaterials, particularly older adults who may experience different responses compared to younger individuals.
✕Less likely to help
Patients who do not have any implants or biomaterials and are not experiencing issues related to fibrosis may not benefit from this research.
What this research studies
This research investigates how senescent cells, which are cells that have stopped dividing, interact with the immune system during the body's response to foreign materials like implants. The study focuses on how these interactions change with age and how they contribute to fibrosis, a condition where tissue becomes thick and scarred. By using advanced techniques to analyze these cells and their communication networks, the research aims to uncover the roles of different cell types in this process. This could lead to better understanding and management of complications related to implants and other biomaterials across different age groups.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing complications from implants and enhance the safety and effectiveness of biomaterials used in medical treatments.
How similar studies have gone: Previous research has shown promising results in understanding the role of senescent cells in various biological processes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Elisseeff, Jennifer H — Johns Hopkins University
- Study coordinator: Elisseeff, Jennifer H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.