Understanding how aging affects testis stem cells
Characterization of age-related changes in the testis stem cell niche
['FUNDING_R21'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11071644
This study looks at how aging affects the tiny environment where sperm-producing stem cells live in fruit flies, helping us understand why fertility might decline as we get older.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11071644 on ClinicalTrials.gov |
What this research studies
This research investigates the changes that occur in the testis stem cell niche as individuals age, focusing on how these changes impact the process of sperm production. By using the adult fruit fly as a model organism, the study aims to identify the intrinsic and extrinsic factors that influence stem cell function and number over time. The research will analyze gene expression in niche cells and the surrounding microenvironment to better understand the decline in stem cell activity associated with aging. This could provide insights into the biological mechanisms behind age-related fertility issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are adult males experiencing age-related fertility issues.
Not a fit: Patients who are not experiencing fertility issues or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing age-related fertility problems in men.
How similar studies have performed: While the specific approach using Drosophila is novel, similar studies have shown success in understanding stem cell aging in other contexts.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BACH, ERIKA A — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: BACH, ERIKA A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.