Understanding how aging affects tendon structure and function
Official title: Age-related mechanisms of altered tendon structure and function
Funded at University of Rochester · NIH-11051186 · Data updated 2026-11-12
This study looks at how getting older affects our tendons, which are important for movement and staying active, and aims to find ways to help tendons heal better and stay healthy as we age, so people can enjoy a better quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $507,183 |
| NIH project number | 5R01AR082667-03 |
| Project ID | NIH-11051186 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing tendon-related issues or injuries.
✕Less likely to help
Patients who are younger and do not have tendon-related problems may not receive benefit from this research.
What this research studies
This research investigates how aging leads to changes in tendon structure and function, which can significantly impact mobility and quality of life. The study focuses on the decline in tendon cell density and its effects on the production of essential components that maintain tendon health. By exploring the molecular changes in tendon cells as they age, the research aims to identify strategies to enhance tendon healing and prevent degeneration. Patients may benefit from insights that could lead to improved treatments for tendon injuries related to aging.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve tendon health and healing in older adults.
How similar studies have gone: Other research has shown promising results in understanding age-related changes in tissues, suggesting potential for success in this area.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Loiselle, Alayna — University of Rochester
- Study coordinator: Loiselle, Alayna
Related research
Other NIH-funded projects on the same topics.
-
Rapid automated breast lump diagnosis without a radiologist or sonographer
A new AI-powered ultrasound tool helps determine if a palpable breast lump is likely benign or malignant, using a simplified technique that can be used by people with minimal ultrasound training.
-
ML-ROVER: Reducing Unneeded Lab Tests in Kids with AI
Aims to use machine learning to cut unnecessary blood tests in children in intensive care, helping avoid anemia and improve care quality.
-
Aggressive fever-reducing therapy to protect the brains of children with CNS malaria
A study planned for children with CNS malaria will test whether aggressive fever-reducing treatment can lower death and brain-related problems.
-
Aggressive fever-reducing therapy to protect brains in children with CNS malaria
A plan to test whether giving strong fever-reducing medications to children with central nervous system malaria can lower death and brain injury.
-
Aggressive fever-fighting treatment to protect the brain in kids with CNS malaria
A plan to test whether giving strong fever-reducing treatment alongside standard care can lower death and brain injury in children with CNS malaria.
-
Aggressive fever-reducing treatment to protect brains in kids with CNS malaria
A plan to test whether giving strong fever-reducing medicine alongside standard malaria treatment can lower deaths and brain injuries in children with CNS malaria.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.