Understanding how aging affects stem cells and their environment
The aging stem cell niche
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-10830255
This study is looking at how getting older affects stem cells and their surroundings in tiny worms, which could help us understand how aging impacts our health and diseases like cancer, with the hope of finding new ways to keep our stem cells healthy as we age.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10830255 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of aging on stem cells and their supporting environment, known as the stem cell niche. By using a model organism called C. elegans, the study aims to explore how age-related changes in the niche affect stem cell function and contribute to health decline and diseases like cancer. The research employs advanced imaging and molecular techniques to uncover the mechanisms behind niche aging and how these can be manipulated to rejuvenate stem cells. This work could lead to new strategies in regenerative medicine, particularly for age-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or conditions linked to stem cell dysfunction.
Not a fit: Patients who are younger and do not have age-related health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that restore stem cell function in older adults, potentially improving health and longevity.
How similar studies have performed: Other research has shown promising results in understanding stem cell aging and its implications for regenerative medicine, indicating that this approach has potential for success.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUBBARD, E. JANE ALBERT — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: HUBBARD, E. JANE ALBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer