Understanding how aging affects schizophrenia and its related health issues
Molecular Mechanisms of Aging in Schizophrenia: Implications of Bioenergetic Metabolism and Redox Biology
This study is looking at how aging affects people with schizophrenia, especially how their brain energy and health might change over time, to help find better ways to support their mental and physical well-being.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project ID | NIH-11020986 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind aging in individuals with schizophrenia, focusing on how bioenergetic metabolism and redox biology contribute to cognitive decline and increased health risks. By examining the biochemical pathways involved, the study aims to uncover why patients with schizophrenia experience accelerated aging and higher rates of dementia. The approach includes analyzing the effects of chronic psychosis and antipsychotic medications on brain function and overall health. Patients may benefit from insights that could lead to improved treatment strategies and better management of their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with schizophrenia who are experiencing cognitive decline or related health issues.
Not a fit: Patients without a diagnosis of schizophrenia or those who are not experiencing cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that improve cognitive function and overall health outcomes for patients with schizophrenia.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between aging and cognitive decline in psychiatric disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
Belmont, United States
- Mclean Hospital — Belmont, United States (Active)
Researchers
- Principal investigator: Du, Fei — Mclean Hospital
- Study coordinator: Du, Fei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.