Understanding how aging affects protein production in blood vessels
Official title: Co-translational Regulation in the Vasculature of Organ Systems with Aging
Funded at University of Illinois at Chicago · NIH-10904957 · Data updated 2026-11-12
This study is looking at how aging affects the way our blood vessels produce proteins, which is important for heart health, and it aims to find out how these changes might contribute to heart problems as we get older.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | August 15, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $199,875 |
| NIH project number | 5R21AG080316-02 |
| Project ID | NIH-10904957 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing cardiovascular issues or those interested in the effects of aging on heart health.
✕Less likely to help
Patients who are young and do not have cardiovascular conditions may not benefit from this research.
What this research studies
This research investigates the process of protein production in blood vessels, particularly how it changes with aging. It focuses on the co-translational regulation of proteins, which involves the simultaneous translation of mRNA and maturation of proteins in the heart's endothelial cells. By using advanced techniques to analyze protein complexes, the study aims to uncover how these processes are altered in aging and how they impact cardiovascular health. This could lead to new insights into the mechanisms of cardiovascular injury and aging.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of cardiovascular issues related to aging.
How similar studies have gone: While there has been significant research on protein production, this approach focusing on co-translational regulation in mammalian systems is relatively novel.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Goldspink, Paul H — University of Illinois at Chicago
- Study coordinator: Goldspink, Paul H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.