Understanding how aging affects protein function in the body
Defining the landscape and mechanisms of protein redox regulation during aging
['FUNDING_R01'] · DANA-FARBER CANCER INST · NIH-10890667
This study is looking at how getting older affects certain proteins in our bodies and how these changes might lead to age-related health issues, with the hope of finding ways to help us age healthier and live longer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DANA-FARBER CANCER INST (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10890667 on ClinicalTrials.gov |
What this research studies
This research investigates how the aging process alters the regulation of proteins in mammalian tissues, focusing on modifications caused by reactive oxygen species (ROS). By utilizing advanced mass spectrometry technology, the study aims to map the changes in protein cysteine residues that occur with age and how these changes contribute to age-related diseases. The researchers will explore the potential for interventions that could improve health and lifespan by modifying these redox regulation networks. This work could provide insights into the biological mechanisms of aging and inform strategies for promoting healthier aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who may be experiencing age-related health issues.
Not a fit: Patients who are not experiencing age-related decline or those with acute conditions unrelated to aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that enhance health and longevity in aging individuals.
How similar studies have performed: Previous research has shown promising results in understanding redox regulation and its impact on aging, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- DANA-FARBER CANCER INST — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHOUCHANI, EDWARD THOMAS — DANA-FARBER CANCER INST
- Study coordinator: CHOUCHANI, EDWARD THOMAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.