Understanding how aging affects platelet production from stem cells
Defining the cause and consequence of aging-specific platelet specification from hematopoietic stem cells
This study looks at how getting older affects the way our bodies make and use platelets, which help stop bleeding, to understand why older adults might have more problems with blood clots and heart issues, with the hope of finding better ways to help them stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project ID | NIH-11094863 on NIH RePORTER |
What this research studies
This research investigates how aging influences the production and function of platelets, which are crucial for preventing bleeding. It focuses on the changes in hematopoietic stem cells, which produce platelets, as they age. By studying these mechanisms, the research aims to uncover why older adults experience more platelet-related disorders. The findings could lead to new strategies for managing conditions like thrombosis and cardiovascular disease in the elderly.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who may be experiencing age-related platelet disorders.
Not a fit: Patients who are young or do not have any platelet-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for platelet-related disorders in older adults.
How similar studies have performed: Other research has shown promising results in understanding age-related changes in blood cell production, indicating that this approach has potential.
Where this research is happening
Santa Cruz, United States
- University of California Santa Cruz — Santa Cruz, United States (Active)
Researchers
- Principal investigator: Forsberg, Camilla — University of California Santa Cruz
- Study coordinator: Forsberg, Camilla
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.