Understanding how aging affects ovarian function
Cellular senescence and epigenomic remodeling in ovarian aging
This study is looking into how aging affects women's ovarian health and fertility, using new genetic tools to understand the changes in cells that happen over time, so we can learn more about maintaining health and longevity as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10848479 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind age-related declines in ovarian function, which are linked to overall health and longevity. By using advanced genetic techniques, the study aims to explore how specific changes in cells contribute to ovarian aging. Researchers will focus on the role of cellular senescence and epigenetic modifications in the depletion of ovarian follicles, which are crucial for fertility. The project utilizes innovative models to isolate genetic material from different ovarian cell types, allowing for a detailed analysis of these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing age-related ovarian dysfunction or those interested in understanding ovarian aging.
Not a fit: Patients who are premenopausal and do not exhibit signs of ovarian dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve ovarian health and extend reproductive lifespan for women.
How similar studies have performed: While research on ovarian aging is ongoing, this specific approach using transgenic models is relatively novel and has not been extensively tested.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Stout, Michael B — Oklahoma Medical Research Foundation
- Study coordinator: Stout, Michael B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.