Understanding how aging affects ovarian cancer spread in the abdomen
Integrative Analysis of the Aging Peritoneum in Metastatic Receptivity
This study is looking at how getting older affects the lining of the abdomen and how that might help ovarian cancer spread, especially in older women, to find better ways to treat the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11007238 on NIH RePORTER |
What this research studies
This research investigates the impact of aging on the peritoneum, the lining of the abdominal cavity, and its role in the spread of ovarian cancer. The principal investigator is conducting experiments using mouse models to explore how age-related changes in the peritoneal environment influence the ability of cancer cells to metastasize. By focusing on older women, who are at a higher risk for ovarian cancer, the research aims to uncover critical insights that could lead to improved treatment strategies. The findings may help identify new therapeutic targets to enhance patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are older women diagnosed with ovarian cancer, particularly those over the age of 63.
Not a fit: Patients with early-stage ovarian cancer or those under the age of 63 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for older women with ovarian cancer.
How similar studies have performed: Previous research has shown promising results in understanding cancer metastasis in relation to aging, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Harper, Elizabeth — Johns Hopkins University
- Study coordinator: Harper, Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.