Understanding how aging affects muscle stem cells
Aging and Stem Cell Resilience
This study is looking at how aging affects muscle stem cells and what happens to them over time, while also exploring if certain diets, like fasting or ketogenic diets, can help keep these cells healthy and strong as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11023094 on NIH RePORTER |
What this research studies
This research investigates the decline in resilience of muscle stem cells (MuSCs) as people age. It focuses on the mechanisms that lead to stem cell exhaustion, particularly how certain signaling pathways, like Notch and p53, change with age and affect cell survival. The study also explores dietary interventions, such as fasting and ketogenic diets, that may enhance the resilience of these stem cells. By identifying the molecular factors involved, the research aims to find ways to maintain MuSC function and prevent age-related decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are interested in understanding age-related changes in muscle health.
Not a fit: Patients who are under 21 years old or do not have concerns related to muscle health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving muscle health and function in older adults.
How similar studies have performed: Previous research has shown promising results in enhancing stem cell resilience through dietary interventions, indicating potential for success in this area.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Rando, Thomas a. — University of California Los Angeles
- Study coordinator: Rando, Thomas a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.