Understanding how aging affects muscle repair
Stem Cell Dysfunction in Aged Skeletal Muscle
This study is looking at how our muscles lose strength as we get older and aims to find out how special cells in our muscles can help repair them after injury, which could lead to better treatments for keeping muscles healthy in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10918347 on NIH RePORTER |
What this research studies
This research investigates the decline in muscle function as we age, focusing on the role of muscle stem cells (MuSCs) in muscle repair. The study aims to uncover the signals that activate these stem cells, which are crucial for repairing muscle tissue after injury. By exploring a newly discovered activation program driven by a specific transcription factor, the research seeks to enhance the regenerative potential of aged muscle stem cells. Patients may benefit from insights that could lead to new therapies for improving muscle health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing muscle weakness or loss of muscle mass.
Not a fit: Patients who are younger than 21 or do not have issues related to muscle repair may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance muscle repair and strength in older adults.
How similar studies have performed: Other research has shown promise in enhancing muscle repair through stem cell activation, making this approach a potentially valuable advancement.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Almada, Albert Ernesto — University of Southern California
- Study coordinator: Almada, Albert Ernesto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.