Understanding how aging affects muscle cells and function
Project 2 - Cellular Senescence and Skeletal Muscle Aging
['FUNDING_P01'] · MAYO CLINIC ROCHESTER · NIH-11079522
This study is looking at how aging affects muscle health by examining certain cells in our muscles that change as we get older, and it aims to find ways to help improve muscle strength and function for older adults.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11079522 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of cellular senescence on skeletal muscle as people age. It focuses on identifying specific cell populations in muscles that become senescent and how this contributes to muscle loss and dysfunction. Using advanced genetic and pharmacological tools, the study aims to explore the roles of certain proteins in muscle aging and assess potential therapeutic compounds that could improve muscle health in older adults. The research employs innovative systems biology approaches and molecular phenotyping to gain deeper insights into muscle aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing muscle loss or dysfunction due to aging.
Not a fit: Patients who are younger or do not have age-related muscle issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve muscle health and function in older adults.
How similar studies have performed: Previous research has shown promising results in understanding muscle aging and the role of cellular senescence, indicating that this approach has potential for success.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEBRASSEUR, NATHAN K — MAYO CLINIC ROCHESTER
- Study coordinator: LEBRASSEUR, NATHAN K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder, age dependent disease