Understanding how aging affects muscle and bone growth
Muscle and Bone Growth in Aging
This study is looking at how aging affects our muscles and bones, especially how a substance called IGF-I helps repair muscles, and it’s for older adults who want to understand how to keep their muscles and bones healthy as they age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10908382 on NIH RePORTER |
What this research studies
This research investigates the decline of muscle and bone integrity as people age, focusing on the role of Insulin-like Growth Factor-I (IGF-I) in muscle growth and regeneration. The study aims to identify the specific muscle cells responsible for producing IGF-I, which is crucial for repairing damaged muscle fibers. Additionally, it explores how muscle contractions influence bone health, particularly in older adults who may experience decreased physical activity. By using innovative mouse models, the research seeks to uncover mechanisms that could enhance muscle and bone health in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing muscle weakness or bone density loss.
Not a fit: Patients who are younger and do not have issues related to muscle or bone health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving muscle and bone health in older adults, potentially reducing the risk of frailty and fractures.
How similar studies have performed: Previous research has shown promising results in understanding the role of growth factors in muscle and bone health, indicating that this approach has potential for success.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Kok, Hui Jean — Indiana University Indianapolis
- Study coordinator: Kok, Hui Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.