Understanding how aging affects mood and reward processing in older adults
Official title: Prediction Error and Affective Salience Abnormalities in Aging and Late-Life Depression
Funded at Weill Medical Coll of Cornell Univ · NIH-10738809 · Data updated 2026-11-12
This study looks at how getting older affects thinking and feelings, especially for older adults dealing with depression, to find better ways to help them feel better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 20, 2019 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $177,070 |
| NIH project number | 5K01MH118480-05 |
| Project ID | NIH-10738809 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing symptoms of depression or mood disorders.
✕Less likely to help
Patients who are not experiencing depression or are younger than the targeted age group may not benefit from this research.
What this research studies
This research investigates how aging impacts cognitive and emotional processes, particularly in older adults experiencing depression. By utilizing advanced computational modeling and neuroimaging techniques, the study aims to identify disruptions in reward and salience mechanisms that may contribute to mood disorders. The findings could help develop personalized treatment strategies for late-life depression, enhancing our understanding of how these processes change with age.
Why it matters
Potential benefit: If successful, this research could lead to more effective, tailored treatments for older adults suffering from depression.
How similar studies have gone: Previous research has shown promise in using computational models to understand cognitive and emotional dysfunctions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Victoria, Lindsay — Weill Medical Coll of Cornell Univ
- Study coordinator: Victoria, Lindsay
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.