Understanding how aging affects memory updating in Alzheimer's disease
Official title: Epigenetic and cellular mechanisms of age-related memory updating impairments
Funded at Pennsylvania State University, the · NIH-10996885 · Data updated 2026-11-12
This study is looking at how aging and Alzheimer's disease make it harder for older adults to update their memories, using a special memory task with mice to understand the role of a specific factor in the brain, which could help us find new ways to improve memory in the future.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $37,124 |
| NIH project number | 1F31AG087533-01A1 |
| Project ID | NIH-10996885 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing memory difficulties, particularly those at risk for or diagnosed with Alzheimer's disease.
✕Less likely to help
Patients who are younger and do not exhibit memory impairments or cognitive decline may not benefit from this research.
What this research studies
This research investigates the molecular and cellular mechanisms that contribute to memory updating difficulties in older adults, particularly those with Alzheimer's disease. By using a novel memory task in mice, the study aims to explore the role of a specific epigenetic factor, HDAC3, in how aging impacts the brain's ability to update memories. The findings could provide insights into the biological changes that occur with age and how they affect cognitive function, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for memory impairments associated with aging and Alzheimer's disease.
How similar studies have gone: While the specific focus on HDAC3 and memory updating in aging is novel, related research has shown promising results in understanding the molecular mechanisms of memory and aging.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Brunswick, Chad Arthur — Pennsylvania State University, the
- Study coordinator: Brunswick, Chad Arthur
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.