Understanding how aging affects lymphoma in older patients
Official title: Project 3 Cerchietti
Funded at Weill Medical Coll of Cornell Univ · NIH-10847990 · Data updated 2026-11-12
This study is looking at why older adults with diffuse large B-cell lymphoma (DLBCL) don’t do as well as younger patients, even when they get the same treatments, by exploring how aging affects the biology of their cancer and finding new ways to help them.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 12, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $419,309 |
| NIH project number | 1P01CA272295-01A1 |
| Project ID | NIH-10847990 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 75 and above who have been diagnosed with diffuse large B-cell lymphoma.
✕Less likely to help
Patients younger than 75 or those with other types of lymphoma may not benefit from this research.
What this research studies
This research investigates the biology of diffuse large B-cell lymphoma (DLBCL) specifically in older individuals aged 75 and above. It aims to uncover why older patients experience worse outcomes despite receiving similar treatments as younger patients. The study will explore the role of epigenetic alterations associated with aging in B cells and how these changes may contribute to the development and progression of DLBCL. By analyzing biological differences in the lymphoma microenvironment, the research seeks to identify potential new therapeutic targets for this vulnerable population.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and outcomes for older patients with DLBCL.
How similar studies have gone: Other research has shown promising results in understanding the biological differences in cancers among older populations, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Cerchietti, Leandro C — Weill Medical Coll of Cornell Univ
- Study coordinator: Cerchietti, Leandro C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.