Understanding how aging affects lung immunity and responses to viral infections
Modulation of lung immunity by epithelial cells from older individuals
['FUNDING_OTHER'] · JACKSON LABORATORY · NIH-11059967
This study looks at how the lung cells of older people respond to viruses like COVID-19 compared to younger people, to help us understand why older adults might have a harder time fighting off infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JACKSON LABORATORY (nih funded) |
| Locations | 1 site (BAR HARBOR, UNITED STATES) |
| Trial ID | NIH-11059967 on ClinicalTrials.gov |
What this research studies
This research investigates how airway epithelial cells from older individuals contribute to changes in lung immunity, particularly in response to viral infections like COVID-19. The study focuses on understanding the differences in immune responses between older and younger individuals, using advanced laboratory techniques to analyze how age affects the immune system's ability to fight off viruses. By examining the behavior of lung cells in a controlled environment, researchers aim to uncover the mechanisms behind age-related immune dysfunction and chronic inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and above, who may be at higher risk for severe outcomes from viral infections.
Not a fit: Patients who are younger than 65 or do not have respiratory issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for respiratory infections in older adults.
How similar studies have performed: Previous research has shown that understanding age-related changes in immune responses can lead to significant advancements in treating age-associated diseases, indicating a promising avenue for this investigation.
Where this research is happening
BAR HARBOR, UNITED STATES
- JACKSON LABORATORY — BAR HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PALUCKA, ANNA KAROLINA — JACKSON LABORATORY
- Study coordinator: PALUCKA, ANNA KAROLINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.