Understanding how aging affects kidney repair
Tubular senescence and proliferative capacity of the aging kidney
['FUNDING_CAREER'] · WASHINGTON UNIVERSITY · NIH-10830367
This study is looking at how aging affects the kidneys' ability to heal after injury, especially focusing on certain kidney cells from younger and older people, and it hopes to find ways to help older adults recover better by boosting a specific protein.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10830367 on ClinicalTrials.gov |
What this research studies
This research investigates how the aging process impacts the kidney's ability to repair itself after injury, particularly focusing on the behavior of specific kidney cells known as proximal tubule cells. By comparing these cells from younger and older individuals, the study aims to identify differences in their ability to grow and recover after damage. The researchers will also explore whether enhancing the activity of a particular protein can improve kidney recovery in older adults. This work is crucial as it addresses a growing health concern for the elderly population, who are at higher risk for kidney-related issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and above, who may be experiencing kidney issues or are at risk for acute kidney injury.
Not a fit: Patients who are younger than 65 or do not have any kidney-related health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve kidney recovery in older adults, potentially reducing the incidence of chronic kidney disease.
How similar studies have performed: Other research has shown promising results in understanding kidney aging and repair mechanisms, indicating that this approach has potential for success.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHANG-PANESSO, MONICA — WASHINGTON UNIVERSITY
- Study coordinator: CHANG-PANESSO, MONICA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome