Understanding how aging affects immune responses to influenza vaccines
Identification of Metabolic and Immune Deficits in the Aged Population and Their Restoration to Achieve Youthful Anti-Influenza Vaccine Responsiveness
['FUNDING_U01'] · DANA-FARBER CANCER INST · NIH-10976440
This study is looking at how getting older affects how well the flu vaccine works for people aged 65 and up, so researchers can find ways to make vaccines better for older adults.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DANA-FARBER CANCER INST (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10976440 on ClinicalTrials.gov |
What this research studies
This research investigates how aging impacts the immune system's response to influenza vaccines, particularly in individuals aged 65 and older. The team will analyze immune cells from both younger and older participants before and after vaccination to identify changes in immune function due to aging. By understanding these changes, the researchers aim to develop new vaccines and treatments that can enhance the immune response in older adults, potentially leading to better protection against influenza. The study will involve detailed assessments of various immune cell types and their metabolic functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are interested in participating in influenza vaccination studies.
Not a fit: Patients under the age of 65 or those with pre-existing severe immune deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective influenza vaccines for older adults, significantly improving their health outcomes.
How similar studies have performed: Previous research has shown promise in understanding immune aging, but this specific approach to restoring vaccine responsiveness in older adults is relatively novel.
Where this research is happening
BOSTON, UNITED STATES
- DANA-FARBER CANCER INST — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARASCO, WAYNE A. — DANA-FARBER CANCER INST
- Study coordinator: MARASCO, WAYNE A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.