Understanding how aging affects immune responses in transplant patients
Official title: Aging and transplant immunity
Funded at Brigham and Women's Hospital · NIH-11083581 · Data updated 2026-11-12
This study is looking at how the immune systems of older and younger people respond differently after receiving a transplant, with the hope of finding better treatments to help older patients have a successful recovery.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 3, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $2,363,918 |
| NIH project number | 5P01AI175397-02 |
| Project ID | NIH-11083581 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older individuals who are awaiting or have received a transplant.
✕Less likely to help
Patients who are younger and do not have age-related immune response issues may not benefit from this research.
What this research studies
This research investigates the differences in immune responses between older and younger transplant recipients. It aims to identify age-specific changes in the immune system that affect how older patients respond to transplants. By studying the cellular and humoral mechanisms of alloimmunity in aging, the research seeks to develop tailored treatments for older transplant recipients. The goal is to improve transplant outcomes by addressing the unique challenges faced by this growing patient population.
Why it matters
Potential benefit: If successful, this research could lead to more effective transplant treatments specifically designed for older patients, improving their health outcomes.
How similar studies have gone: Previous research has indicated that age-related differences in immune responses exist, suggesting that this approach could yield significant insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Abdi, Reza — Brigham and Women's Hospital
- Study coordinator: Abdi, Reza
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.