Understanding how aging affects immune responses in organ transplant patients
Official title: Antibody Mediated Rejection and Post-transplantation Anti-Viral Immunity in Aging
Funded at Brigham and Women's Hospital · NIH-11083608 · Data updated 2026-11-12
This study is looking at how the immune systems of older patients who receive organ transplants work differently than those of younger patients, especially focusing on certain immune cells that help manage organ rejection, with the goal of finding better treatments to help older patients have successful transplants.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 3, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $694,998 |
| NIH project number | 5P01AI175397-02 |
| Project ID | NIH-11083608 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who are undergoing or have undergone solid organ transplantation.
✕Less likely to help
Patients under the age of 65 or those who are not undergoing organ transplantation may not benefit from this research.
What this research studies
This research investigates the unique immune responses of older patients undergoing solid organ transplantation, focusing on how their immune systems differ from younger patients. It aims to understand the role of T follicular helper (Tfh) cells in mediating rejection of transplanted organs and how these cells may be altered by aging. The study will explore how the aging process affects these immune cells and their ability to respond to infections and transplant rejection. By identifying specific stages of Tfh cells, the research seeks to develop targeted therapies that could improve transplant outcomes for older patients.
Why it matters
Potential benefit: If successful, this research could lead to improved transplant outcomes and reduced infections for older patients receiving organ transplants.
How similar studies have gone: Previous research has shown that understanding immune responses in aging populations can lead to better treatment strategies, suggesting potential success for this approach.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Sage, Peter the — Brigham and Women's Hospital
- Study coordinator: Sage, Peter the
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.