Understanding how aging affects immune cells and inflammation
Official title: Mitochondrial Malfunction in T Cell Aging and Tissue Inflammation
Funded at Mayo Clinic Rochester · NIH-11045736 · Data updated 2026-11-12
This study looks at how getting older affects T cells, which are important for our immune system, especially in older adults with rheumatoid arthritis, to understand how problems with cell energy can lead to more inflammation and weaker immunity.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $563,609 |
| NIH project number | 5U01AI179609-02 |
| Project ID | NIH-11045736 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those with autoimmune diseases like rheumatoid arthritis.
✕Less likely to help
Patients who are younger and do not have age-related immune issues or autoimmune diseases may not benefit from this research.
What this research studies
This research investigates the impact of aging on T cells, which are crucial components of the immune system. It focuses on how mitochondrial dysfunction in these cells leads to increased inflammation and reduced immunity, particularly in older adults. By studying patients with rheumatoid arthritis, the research aims to uncover the mechanisms behind premature aging of T cells and their role in tissue damage. The approach includes examining mitochondrial behavior and its effects on immune responses.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune function and reducing inflammation in older adults.
How similar studies have gone: Previous research has shown promising results in understanding immune aging and its implications, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Weyand, Cornelia M. — Mayo Clinic Rochester
- Study coordinator: Weyand, Cornelia M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.