Understanding how aging affects immune cells and inflammation
Mitochondrial Malfunction in T Cell Aging and Tissue Inflammation
This study looks at how getting older affects T cells, which are important for our immune system, especially in older adults with rheumatoid arthritis, to understand how problems with cell energy can lead to more inflammation and weaker immunity.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11045736 on NIH RePORTER |
What this research studies
This research investigates the impact of aging on T cells, which are crucial components of the immune system. It focuses on how mitochondrial dysfunction in these cells leads to increased inflammation and reduced immunity, particularly in older adults. By studying patients with rheumatoid arthritis, the research aims to uncover the mechanisms behind premature aging of T cells and their role in tissue damage. The approach includes examining mitochondrial behavior and its effects on immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those with autoimmune diseases like rheumatoid arthritis.
Not a fit: Patients who are younger and do not have age-related immune issues or autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune function and reducing inflammation in older adults.
How similar studies have performed: Previous research has shown promising results in understanding immune aging and its implications, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Weyand, Cornelia M. — Mayo Clinic Rochester
- Study coordinator: Weyand, Cornelia M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.