Understanding how aging affects immune cell function and inflammation
Official title: Cellular senescence and Associated Lysosomal Dysfunction in Immune Aging
Funded at Buck Institute for Research on Aging · NIH-11043347 · Data updated 2026-11-12
This study is looking at how aging affects the immune system and causes long-lasting inflammation, and it’s for older adults who might help by giving blood samples to help us learn more about these changes and their impact on health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $671,861 |
| NIH project number | 5U01AI180158-02 |
| Project ID | NIH-11043347 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are older adults who may be experiencing age-related health issues or immune dysfunction.
✕Less likely to help
Patients who are younger and do not have age-related conditions may not benefit from this research.
What this research studies
This research investigates how cellular senescence, a process related to aging, impacts the immune system and contributes to chronic inflammation. It focuses on the accumulation of damaged cells that can trigger immune responses, potentially leading to age-related diseases. By analyzing immune cells and their behavior in older individuals, the study aims to uncover the mechanisms behind immune aging and its effects on overall health. Patients may be involved in providing blood samples to help researchers understand these processes better.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving immune function and reducing inflammation in older adults.
How similar studies have gone: Previous research has shown promising results in understanding the role of cellular senescence in aging and its impact on health, indicating that this approach is building on established findings.
Where this research is happening
-
Buck Institute for Research on Aging
Novato, United States Active
Researchers
- Principal investigator: Verdin, Eric M. — Buck Institute for Research on Aging
- Study coordinator: Verdin, Eric M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.