Understanding how aging affects immune cell behavior related to tumors
Official title: Dissecting the hematopoietic pathways governing age-associated pathogenic myelopoiesis
Funded at Icahn School of Medicine at Mount Sinai · NIH-11107779 · Data updated 2026-11-12
This study is looking at how certain immune cells change as we get older and how these changes might lead to inflammation and cancer, with the goal of finding better ways to manage cancer risks for older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $680,334 |
| NIH project number | 1R01CA301057-01 |
| Project ID | NIH-11107779 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over the age of 21 who may be experiencing age-related health issues or are at risk for tumors.
✕Less likely to help
Patients under the age of 21 or those with non-age-related conditions may not benefit from this research.
What this research studies
This research investigates the role of myeloid cells, such as monocytes and macrophages, in the immune response as we age, particularly how they contribute to chronic inflammation and tumor progression. The study aims to identify the specific molecular mechanisms that lead to age-associated changes in these immune cells, which may promote tumor growth. By utilizing advanced profiling techniques, the researchers will explore how these immune cells evolve from embryonic origins to adulthood and how their functions change with age. This could lead to new insights into how to better manage age-related cancer risks.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating age-related cancers by targeting the immune system.
How similar studies have gone: Previous research has shown that targeting immune pathways can effectively alter tumor progression, suggesting potential success for this approach.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Merad, Miriam — Icahn School of Medicine at Mount Sinai
- Study coordinator: Merad, Miriam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.