Understanding how aging affects heart function and structure
Official title: Regulation of Mechanical Coupling in Aging Myocardium
Funded at Rhode Island Hospital · NIH-11116885 · Data updated 2026-11-12
This study looks at how getting older affects the heart and what happens at the tiny cellular level, especially focusing on certain proteins that help keep the heart working well, so we can find ways to protect heart health as we age.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | June 15, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $241,080 |
| NIH project number | 5R21AG077036-02 |
| Project ID | NIH-11116885 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related changes in heart function.
✕Less likely to help
Patients with overt cardiovascular diseases may not benefit from this research.
What this research studies
This research investigates how aging impacts the heart's structure and function, focusing on the cellular and molecular changes that occur as we age. It aims to explore the role of cytoskeletal proteins in maintaining heart function despite age-related changes. By studying the connections between specific proteins in the heart, the research seeks to uncover mechanisms that may help protect the heart as it ages. The approach involves testing hypotheses in mouse models to gain insights into the aging heart's mechanics.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving heart function in older adults.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of cardiac aging, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Rhode Island Hospital
Providence, United States Active
Researchers
- Principal investigator: Radice, Glenn Lawrence — Rhode Island Hospital
- Study coordinator: Radice, Glenn Lawrence
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.