Understanding how aging affects heart function and structure
Regulation of Mechanical Coupling in Aging Myocardium
['FUNDING_R21'] · RHODE ISLAND HOSPITAL · NIH-11116885
This study looks at how getting older affects the heart and what happens at the tiny cellular level, especially focusing on certain proteins that help keep the heart working well, so we can find ways to protect heart health as we age.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RHODE ISLAND HOSPITAL (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-11116885 on ClinicalTrials.gov |
What this research studies
This research investigates how aging impacts the heart's structure and function, focusing on the cellular and molecular changes that occur as we age. It aims to explore the role of cytoskeletal proteins in maintaining heart function despite age-related changes. By studying the connections between specific proteins in the heart, the research seeks to uncover mechanisms that may help protect the heart as it ages. The approach involves testing hypotheses in mouse models to gain insights into the aging heart's mechanics.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related changes in heart function.
Not a fit: Patients with overt cardiovascular diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving heart function in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of cardiac aging, suggesting that this approach may yield valuable insights.
Where this research is happening
PROVIDENCE, UNITED STATES
- RHODE ISLAND HOSPITAL — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RADICE, GLENN LAWRENCE — RHODE ISLAND HOSPITAL
- Study coordinator: RADICE, GLENN LAWRENCE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.