Understanding how aging affects heart function
Molecular choreography and trafficking in the aging myocardium
This study looks at how aging affects the heart and what happens to heart cells over time, especially focusing on a process that helps manage proteins in those cells, which can lead to heart problems in older adults; by understanding these changes, we hope to find ways to improve heart health for seniors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11062195 on NIH RePORTER |
What this research studies
This research investigates the molecular changes in the heart as people age, particularly focusing on how these changes lead to decreased heart function. It examines the endosomal pathway, which is responsible for managing proteins in heart cells, and how its deterioration contributes to issues like diastolic dysfunction. By studying these mechanisms, the research aims to uncover potential targets for improving heart health in older adults. Patients may be involved in assessments that help identify these molecular changes and their effects on heart performance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may be experiencing heart-related issues or age-associated decline in heart function.
Not a fit: Patients under the age of 65 or those without any cardiovascular concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and overall health in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the molecular mechanisms of aging in other contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Dixon, Rose Ellen — University of California at Davis
- Study coordinator: Dixon, Rose Ellen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.