Understanding how aging affects gene regulation
Mechanisms of enhancer regulation in aging and age-related diseases
This study is looking at how changes in certain parts of our DNA, called enhancers, affect how we age and develop age-related diseases, with the hope of finding new ways to improve health as we get older.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11086846 on NIH RePORTER |
What this research studies
This research investigates the role of three-dimensional (3D) enhancer regulation in the aging process and age-related diseases. It focuses on how changes in the structure and function of enhancers, which are crucial for gene expression, contribute to the decline in tissue function and the onset of diseases as we age. By examining how these enhancer hubs respond to stress and their regulatory mechanisms, the research aims to uncover new insights into the biological processes of aging. Patients may benefit from a better understanding of how aging impacts health and the potential for targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or diseases.
Not a fit: Patients who are not experiencing age-related conditions or are significantly younger may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases.
How similar studies have performed: Other research has shown promising results in understanding epigenetic changes related to aging, suggesting that this approach could yield valuable insights.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Wang, Lu — University of Texas Hlth Science Center
- Study coordinator: Wang, Lu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.