Understanding how aging affects fat cells
Effect of Aging on Preadipocyte Differentiation
This work explores how aging cells contribute to chronic diseases like Alzheimer's, aiming to find new ways to keep us healthier longer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11231917 on NIH RePORTER |
What this research studies
Aging is a major factor in many long-term health problems, and this research looks at a core reason for aging called cellular senescence. These 'senescent' cells can cause inflammation and spread dysfunction throughout the body, contributing to age-related diseases. Our goal is to develop treatments that specifically target and remove these senescent cells. We are working to translate these discoveries into new therapies that could improve overall health as we age.
Who could benefit from this research
Good fit: This research is relevant for individuals concerned about age-related chronic diseases, including those with or at risk for Alzheimer's disease.
Not a fit: Patients without age-related conditions or those whose conditions are not linked to cellular senescence may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that delay or prevent a wide range of age-related diseases, including conditions like Alzheimer's.
How similar studies have performed: The researchers have already identified and demonstrated the effectiveness of 'senolytic drugs' that target senescent cells, suggesting promising progress in this area.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Kirkland, James L. — Cedars-Sinai Medical Center
- Study coordinator: Kirkland, James L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.