Understanding how aging affects fat cell function and diabetes risk
Metabolic consequences of adipocyte progenitor replicative senescence: mechanism and intervention
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-10796966
This study looks at how getting older affects fat cells and their ability to work well, especially for people dealing with obesity and diabetes, and it aims to find ways to help improve health by understanding how diet and age influence the creation of new fat cells.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10796966 on ClinicalTrials.gov |
What this research studies
This research investigates how the aging process impacts the ability of fat cells to function properly, particularly in relation to obesity and diabetes. It focuses on the role of adipocyte progenitor cells, which are responsible for creating new fat cells, and how their ability to replicate changes with age and diet. By examining the mechanisms behind fat cell turnover and the effects of a high-fat diet, the research aims to identify potential interventions that could improve metabolic health and reduce diabetes risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are experiencing obesity or are at risk for type-2 diabetes, particularly those with metabolic health concerns.
Not a fit: Patients who are not overweight or do not have metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating type-2 diabetes by enhancing fat cell function.
How similar studies have performed: Previous research has shown promising results in understanding the role of fat cell dynamics in metabolic health, suggesting that this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOLONIN, MIKHAIL G — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: KOLONIN, MIKHAIL G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.