Understanding how aging affects egg cell quality in women.
Official title: Investigating ribosome biogenesis and function in the aging mammalian oocyte.
Funded at Stowers Institute for Medical Research · NIH-10996993 · Data updated 2026-11-12
This study looks at how women's egg quality changes as they get older, especially after their mid-thirties, to better understand fertility challenges and help find ways to improve reproductive health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stowers Institute for Medical Research NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $32,974 |
| NIH project number | 1F31HD116553-01 |
| Project ID | NIH-10996993 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing age-related fertility issues, particularly those over 35 years old.
✕Less likely to help
Patients who are younger than 35 and do not have fertility concerns may not benefit from this research.
What this research studies
This research investigates the decline in egg cell quality as women age, particularly starting in their mid-thirties. It aims to uncover the molecular mechanisms that contribute to fertility issues, such as chromosome abnormalities and prolonged time to conception. By studying the biology of egg cells, the research seeks to improve understanding of how age impacts reproductive health and may inform future treatments or interventions. The project utilizes advanced techniques to analyze the cellular components involved in egg cell function and quality.
Why it matters
Potential benefit: If successful, this research could lead to improved fertility treatments and better outcomes for women trying to conceive later in life.
How similar studies have gone: While the decline in egg quality with age is a known issue, this specific investigation into the molecular mechanisms is relatively novel and has not been extensively studied.
Where this research is happening
-
Stowers Institute for Medical Research
Kansas City, United States Active
Researchers
- Principal investigator: Galligos, Anna — Stowers Institute for Medical Research
- Study coordinator: Galligos, Anna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.